Bush stars in Lions win
The Detroit Lions moved into a first-place tie with Chicago in the NFC North thanks to a 40-32 victory over the Bears at Ford Field on Sunday.
Reggie Bush, who missed last weekend's win over the Washington Redskins due to a knee injury, ran for 139 yards on 18 carries, including a 37-yard touchdown run as the Lions (3-1) rallied from 10-6 down early in the second quarter with 24 straight points.
The Kansas City Chiefs improved to 4-0 for the first time in a decade with a 31-7 romp against the injury-depleted New York Giants.
Alex Smith completed 24 of 41 passes for a season-high 288 yards with three TDs as the 2011 Super Bowl champions slumped to 0-4.
Brian Hoyer threw two TD passes in his first home start to guide Cleveland to a 17-6 success against the Cincinnati Bengals. Hoyer connected with Chris Ogbonnaya on a one-yard score to give the Browns (2-2) an 11-point cushion with 4:54 left on the clock.
London's love affair with the NFL grew ever stronger as Adrian Peterson lit up a sold-out Wembley to lead the Minnesota Vikings to a thrilling 34-27 win over the Pittsburgh Steelers.
The reigning MVP scored two touchdowns and ran for 140 yards as the Vikings prevailed in an enthralling contest between two previously winless teams desperate to save their seasons.
The Seattle Seahawks achieved the first 4-0 start in franchise history courtesy of a 23-20 win against the Houston Texans (2-2), Steven Hauschka's overtime field goal proving decisive.
The Arizona Cardinals overturned a 10-point fourth-quarter deficit to topple Tampa Bay 13-10. Jay Feely kicked a 27-yard field goal 1:29 from the end to condemn the Buccaneers (0-4) to their third final-minute loss of the season.
Rookie linebacker Kiko Alonso's second interception of the game with 57 seconds left clinched a 23-20 victory for the Buffalo Bulls against the Baltimore Ravens.
Aaron Williams also intercepted Joe Flacco twice - Flacco threw a career-worst five interceptions - while EJ Manuel threw a 42-yard TD pass to fellow rookie Robert Woods to put the Bills in control.
The Jacksonville Jaguars remained winless after Indianapolis stormed to a 37-3 triumph. Andrew Luck hurled two TD passes while Trent Richardson ran for one score for the Colts (3-1).