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South Africa batsman JP Duminy could miss up to six months after rupturing an Achilles tendon after the first day's play against Australia.
Duminy was taking part in warm-down exercises on the Gabba outfield in Brisbane after day one of the opening Test when he fell to the turf clutching his left leg.
He was rushed to hospital where the severity of the injury was confirmed.
South Africa team manager Dr Mohammed Moosajee said: "At first assessment JP said he heard a loud clicking sound and it felt like he had been hit by an object.
"The diagnosis of an Achilles tendon rupture was confirmed by the MRI scan this evening and he will undergo surgery to re-attach the tendon on Saturday morning.
"Injuries of this nature are caused by a sudden contraction against the direction of movement by the calf muscle as was the case during his sprint.
"We will only be able to gauge further down the line on an expected recovery date, but injuries of this nature have been known to take up to six months before the player can resume playing cricket.
"He is obviously disappointed, but JP, being JP, is trying his best to stay positive, he says everything happens for a reason."
The Proteas' 12th man Francois du Plessis will field in Duminy's place in Brisbane but will not be able to bat.