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Eintracht Frankfurt beat Freiburg to maintain their unbeaten start to the Bundesliga season but Wolfsburg were beaten again by Mainz.
Max Kruse gave Freiburg a shock lead at the Waldstadion in the 50th minute after Christian Streich's side had spent much of the game defending.
Alexander Meier had a goal ruled out for offside, but there was no doubt over his third and fourth goals of the season, which earned the home side a fifth win in six games.
Karim Guede made matters worse for the visitors when he was given his marching orders in stoppage time.
Meanwhile, Wolfsburg's home misery continued as they were beaten 2-0 by Mainz at the VW-Arena, leaving them languishing in the bottom three of the table.
Junior Diaz's first goal in a Mainz shirt and an Adam Szalai effort gave the visitors a two-goal lead before the interval.
Wolfsburg were unable to recover in the second half, wasting chance after chance as their curse at home, where they have not won all season, continued.