Fulham could be boosted by the return of a host of players from injury, including veterans Damien Duff, John Arne Riise and first-choice goalkeeper Mark Schwarzer.
Mladen Petric is also expected to be available again.
Martin Jol has also been buoyed by the news that Mahamadou Diarra has been excused Africa Cup of Nations duty, but the Mali midfielder is still struggling from a knee injury.
Midfielder Roger Espinoza is set to make his Wigan debut at Craven Cottage.
The Honduras international, signed from Sporting Kansas City, stayed on the bench in last weekend's FA Cup tie against Bournemouth, having only arrived in the UK two days before, but now has a week's training under his belt.
Fellow new boy Angelo Henriquez is pushing for a start after impressing as a substitute last weekend, but defenders Antolin Alcaraz (groin) and Adrian Lopez (hamstring) and midfielders Ben Watson (broken leg), Albert Crusat (knee) and Ryo Miyaichi (ankle) are all out.
