Hampshire in control
Hampshire's slow left-armer Danny Briggs claimed four wickets to leave County Championship Division Two bottom side Derbyshire in trouble.
They finished the second day at the Ageas Bowl on 166 for seven, still 222 runs behind, and with no recognised batsmen left face an uphill struggle.
The visitors had done a good job of polishing off the leaders' innings in the morning as once Michael Bates was removed having made his first half-century against Derbyshire, Mark Footitt finished off the tail.
With only 56 added to the overnight total Derbyshire at least had some momentum but the loss of Paul Borrington to Briggs just before lunch curtailed their progress.
Sean Ervine had Wayne Madsen caught at slip and bad light forced an early tea with Stephen Moore still unbeaten on 48.
Upon the resumption, the 23-year-old Briggs was back in the action, trapping Marcus North lbw but Kyle Abbott's removal of half-century maker Moore in similar fashion dealt the real blow.
At 101 for four, Derbyshire were in trouble but Scott Elstone (25) and Alex Hughes (32) fought back with a partnership of 59 which was eventually broken when Ervine took another good catch at slip to give Briggs his third victim.
Gareth Cross fell cheaply to Abbott before the Briggs-Elstone combination accounted for Hughes to leave Derbyshire still needing 73 runs to avoid the follow on.
Briggs closed with four for 29 off 22 overs with his sights set on eclipsing his career-best figures of six for 45.