London Irish v Saracens
Ireland scrum-half Tomas O'Leary captains London Irish in their Premiership clash against Saracens.
England wing Marland Yarde starts on the right wing with Sailosi Tagicakibau on the opposite flank and Topsy Ojo at full-back.
New Saracens signing Billy Vunipola starts at blindside flanker. British and Irish Lions Matt Stevens, Owen Farrell and Brad Barritt also start with Mako Vunipola on the bench.