Manning leads Giants to win
The New York Giants claimed a 27-23 victory over the Washington Redskins in a thrilling finish on Sunday, while New Orleans Saints also won.
Eli Manning's 77-yard touchdown pass to Victor Cruz with 73 seconds left lifted the Giants to victory.
Only 19 seconds earlier, Washington's rookie quarterback Robert Griffin III had thrown a 30-yard touchdown pass to Santana Moss to put the Redskins up, having kept the drive alive with some outstanding running.
But Manning had the final word to keep the Giants out front in the NFC East.
Drew Brees threw for 377 yards and four touchdowns as the New Orleans Saints marked Jonathan Vilma's return from suspension with a 35-28 come-from-behind win over the Tampa Bay Buccaneers.
Vilma played for the first time after being banned for his role in the Saints' bounty-scheme scandal, and helped the Saints to a second straight win after an 0-4 start to the season.
The Saints trailed by 14 before scoring on four straight possessions to lead 28-21 at half-time.
Aaron Rodgers overwhelmed St Louis to hand the Rams their first home loss of the season, 30-20 to the Green Bay Packers.
Rodgers threw for 342 yards and three touchdowns as the Packers moved to 4-3.
Andrew Luck scored two running touchdowns - the first Indianapolis Colts quarterback to do so since 1988 - as they beat the Cleveland Browns 17-13 to level their record at 3-3.
Luck ran in from three and five yards in the first half.
The Cleveland Browns, under new ownership after the sale of the team to Jimmy Haslam was confirmed this week, have lost 11 straight road games.
Dan Bailey kicked the last of his four field goals late in the fourth quarter to lift the Dallas Cowboys to a 19-14 victory over the Carolina Panthers.
Tony Romo threw for 227 yards and a touchdown, but the Cowboys won on the back of Bailey's boot as he kicked the go-ahead field goal with 3:25 to go, and added another inside the final minute.
Nate Washington hauled in a touchdown pass from Matt Hasselbeck with 63 seconds left as the Tennessee Titans edged out the Buffalo Bills 35-34.
Chris Johnson had rushed for 195 yards and two touchdowns, but for a second week running it was left to Hasselbeck to bail out the Titans in the fourth quarter.
Matt Schaub threw for two touchdowns and Arian Foster ran in two more as the Houston Texans romped to a 43-13 victory over the Baltimore Ravens.
Terrell Suggs returned for Baltimore after off-season surgery and had a sack and three tackles, but the Ravens were otherwise overwhelmed as they lost to Houston for the first time in seven meetings.
The Minnesota Vikings had to hang on to beat the Arizona Cardinals 21-14.
When Harrison Smith returned an interception for a touchdown to start the second half, the Vikings led 21-7, but then had to hang on as they offence never got going in the second half.