Manning sets TD record
Peyton Manning broke the NFL's single-season touchdown record as Denver Broncos secured the AFC West title with a 37-13 win at Houston Texans.
Manning's four touchdown passes at Reliant Stadium took him to 51 for the season, surpassing the mark set by Tom Brady in the 2007 season.
The 12-3 Broncos are on the road in Oakland in the final week of the regular season and, if Brady's New England Patriots beat Baltimore Ravens later on Sunday, will still need another victory to be certain of the AFC's top seed and home-field advantage throughout the play-offs.
Manning, who threw three of his touchdowns in the fourth quarter and finished with 400 yards through the air, needs another 266 passing yards to break Drew Brees' record from 2011 of 5,476 in a season.
Kansas City Chiefs' 23-7 defeat at Indianapolis Colts handed the Broncos their third straight division crown - and means the Chiefs (11-4) will be fifth seeds in the AFC regardless of what happens next week.
The Patriots were confirmed as AFC East champions for the fifth year in a row when Miami Dolphins went down 19-0 at Buffalo Bills.
The Dolphins, who drop to 8-7 but can still make the play-offs as a wildcard, managed just 103 yards of offence and six first downs.
Cincinnati Bengals also booked a play-off spot in Sunday's early tranche of games.
Bengals quarterback Andy Dalton threw for 366 yards and four touchdowns - including two to AJ Green - during a 42-14 demolition of Minnesota Vikings.
Cincinnati (10-5) will be crowned AFC North champions if the Ravens lose later in the day.
Romo strikes late
Tony Romo kept Dallas Cowboys' season alive by leading a nine-play, 87-yard touchdown drive late in the fourth quarter of their 24-23 victory at Washington Redskins.
On fourth-and-10 at the Washington 10-yard line with just over a minute left on the clock, Romo hit running back DeMarco Murray with a 10-yard pass after escaping from pocket pressure to extend the play.
The Cowboys (8-7) host Philadelphia Eagles next Sunday in a winner-takes-all showdown for the NFC East title.
In games with no play-off implications, Geno Smith threw two touchdowns and ran in another to inspire New York Jets to a 24-13 success at home to Cleveland Browns and Zac Stacy had 104 rushing yards on 33 carries in St Louis Rams' 23-13 win against Tampa Bay Buccaneers.
Meanwhile, Tennessee Titans ended a three-game losing streak with a 20-16 triumph at Jacksonville Jaguars, guaranteeing they will finish second to the Colts in the AFC South.