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Melodic Rendezvous provided trainer Jeremy Scott and jockey Nick Scholfield with their first Grade One success in the Tolworth Hurdle.
Sent off at 7-2, the seven-year-old had finished runner-up to Champagne Fever in the Punchestown Champion Bumper last April before opening his account over timber last month at Cheltenham.
Nicky Henderson's Royal Boy had finished behind him that day but was favourite to gain his revenge and took the field along with Pendra.
The eventual winner and Court Minstrel were travelling well turning in and when Royal Boy made yet another blunder at the second-last Melodic Rendezvous made his challenge.
Pendra stuck gamely to the task but lost his unbeaten record, beaten four and a half lengths.
Paddy Power went 16-1 from 25s for the Supreme in March and go the same price for the Neptune.