Sir Henry Cecil feels the Red Mills Irish Champion Stakes doesn't fit into Frankel's schedule and has taken him out of the Leopardstown race.
The four-year-old son of Galileo stretched his unbeaten record to 10 races with a devastating performance in the JLT Lockinge Stakes at Newbury on Saturday.
Frankel will not, however, take up an assignment in Ireland on September 8, for which stablemate Twice Over is still one of 50 entries.
Cecil told the Guardian: "It's a great race and everything, but it's not in his programme.
"If, say, he's going to go for the Sussex Stakes (Goodwood, August 1) and then the Juddmonte (York, August 22), then he can't run in that, too. We can't enter him in everything."
