Real falter, Valencia triumph
Jose Mourinho came under more pressure after Real Madrid could only draw at bottom-three side Osasuna, while Valencia beat Sevilla.
Elsewhere, Espanyol claimed a welcome win over Celta Vigo and Real Valladolid beat Real Mallorca.
The heat on Mourinho is set to increase after a poor performance by Real Madrid saw them come away from bottom side Osasuna with just a point after a 0-0 draw.
It was a miserable night for Madrid, who were without the suspended Cristiano Ronaldo and Sergio Ramos, with Kaka sent off 19 minutes after coming on as a substitute while Jose Maria Callejon had a goal disallowed for a borderline offside decision.
The result means Madrid are 15 points behind Primera Division leaders Barcelona, who play Malaga on Sunday, and four behind neighbours Atletico.
Valencia moved into seventh place with a 2-0 victory at home to Sevilla as Roberto Soldado's double secured the win.
The Spanish striker struck shortly after the break, poking home from point-blank range after Adil Rami's corner, then added another in the dying minutes to seal the triumph.
Sergio Garcia's first-half goal was enough to hand Espanyol a crucial three points as they moved out of the Primera Division relegation zone with a 1-0 win over Celta Vigo.
The former Spanish international gave the hosts the perfect start as he tapped home Christian Stuani's cross from close range on 23 minutes, and despite having more of the ball after the break, Celta struggled to create clear-cut chances.
Patrick Ebert inspired Real Valladolid with two goals and an assist as they claimed their first win in five games by beating Real Mallorca 3-1.
The German fired the hosts into the lead with a wonderful strike from 20 yards after 21 minutes but Mallorca were level before half-time as Victor rose to head home Javier Arizmendi's cross 16 minutes later.
Both sides then had their chances to win the game but Ebert proved the difference in the dying minutes as Oscar Gonzalez turned home his cross three minutes from time and the former Hertha Berlin man then rounded off his afternoon as he was sent through on goal and jinked past Dudu Aouate before slotting into an empty net.