Saints sink Rs, City's high five
Southampton beat fellow Premier League strugglers QPR 3-1 on Saturday, while West Brom, Liverpool, Swansea, Reading and Manchester City won.
City moved into top spot with a 5-0 win over Aston Villa ahead of Manchester United's late kick-off against Norwich.
David Silva scored the opener from close range just before half-time before Sergio Aguero scored from the penalty spot after Ciaran Clark handled the ball in the area.
Carlos Tevez added City's third from the spot when Barry Bannan was also adjudged to have handled the ball before Aguero fired his second and Tevez did the same in a resounding win at the Etihad Stadium.
Goals for Rickie Lambert and Jason Puncheon helped to seal a vital 3-1 win for struggling Southampton against QPR at Loftus Road .
Lambert headed in from close range before Puncheon added the second from 20 yards, with Junior Hoilett's second-half header not enough for Mark Hughes' side, as Anton Ferdinand's own goal in the 83rd minute compounded QPR's woes.
Luis Suarez scored a brace as Liverpool beat Wigan 3-0 at Anfield.
The Uruguay international beat Ali Al Habsi twice in the second half with strikes from the middle of the area as Liverpool moved closer to the top half of the table, with Jose Enrique's tap-in sealing the win for Reds boss Brendan Rodgers.
Reading came from behind to earn their first Premier League win this season with a 2-1 win over Everton at the Madejski Stadium.
Poor defending by Reading allowed Steven Naismith to open the scoring for the Toffees before Adam Le Fondre marked his return to the Royals side by equalising with a glancing header.
Everton's Seamus Coleman then conceded a penalty which Le Fondre duly converted to earn a much-needed three points for coach Brian McDermott.
At The Hawthorns, West Brom beat Chelsea 2-1 thanks to goals from Shane Long and Peter Odemwingie.
Long opened the scoring in the 10th minute before Eden Hazard equalised for Chelsea on the stroke of half-time, however, Odemwingie headed past Petr Cech from Long's assist to earn the Baggies another win.
Elsewhere, Swansea beat Newcastle 2-1 St James' Park thanks in part to a blunder by Magpies keeper Tim Krul.
Krul miscued a clearance straight to Pablo Hernandez, who picked out Michu with a great cross, allowing the Spaniard to head the ball past Krul and into the net.
Jonathan de Guzman sealed the win late in the game when he followed up substitute Danny Graham's blocked strike with Demba Ba's stoppage time score not enough for Newcastle.