The Titans may miss out on a Champions League Twenty20 semi-final place after losing by 99 runs to the Kolkata Knight Riders in Cape Town.
The Indian Premier League champions have endured a miserable tournament, but emphatically claimed their first win in their fourth and final game in Group A.
After posting 188 for five batting first the Knight Riders swept through the South Africans for 89 in 16.4 overs.
Lakshmipathy Balaji led the way with four for 19 as the Titans folded to lose their last nine wickets for 38 runs.
It leaves them in danger of missing out on the semi-finals as they sit second, with a two-point cushion over the Auckland Aces, going into the final round of matches.
The Knight Riders ran up a large total on the back of an all-round batting performance that included eight sixes and 19 fours.
Opener Gautam Gambhir top-scored with 44 from 36 balls before Debabrata Das supplied the late fireworks with an unbeaten 43 from 19 balls.
The Titans made a solid start to their chase, but after reaching 51 for one Balaji removed Heino Kuhn and Martin van Jaarsveld from consecutive balls to spark the collapse.
