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Jonathan Trott warmed up for England duty with an unbeaten 41 as Warwickshire cruised to a nine-wicket CB40 win over Derbyshire at Edgbaston.
Trott, in his final innings before Thursday's Lord's Test against West Indies, shared in a 124-run second-wicket stand with William Porterfield (81 not out) as Warwickshire won the battle of the leading two sides in Group C with 15.3 overs to spare.
Derbyshire had earlier been bowled out for 122 with former Falcons captain Rikki Clarke taking three wickets and holding two catches against his old county.
Trott's England team-mate Alastair Cook was also amongst the runs but he could not prevent Essex from suffering a heavy defeat in their Group A clash with Worcestershire in Chelmsford.
Cook contributed 47 to an opening stand of 84 with Mark Pettini (64) but Essex were limited to 190 for nine from their 40 overs and Worcestershire knocked that target off for the loss of just three wickets with 37 balls to spare.
Moeen Ali led the way with a superb 99 having put on 104 for the first wicket with Vikram Solanki (48) as Worcestershire picked up their first win in Group A.
In the same group, Gloucestershire recorded their second win of this season's competition after thrashing Leicestershire by 164 runs at Bristol.
Highly-rated New Zealander Kane Williamson scored a career best one-day score of 122 and Benny Howell 88 as the hosts ran up a formidable 294 for six, and then England Under-19 international Chris Dent claimed four for 43 as Leicestershire were bowled out for 130.
In Group B, Scotland's match with Glamorgan at Bothwell Castle was abandoned after just 6.5 overs due to rain with the home side on 25 for one batting first.
Sussex were also big winners in Group C, beating Unicorns by 144 runs at Hove in their opening match of the tournament.
Matt Machan, playing in only his third List A game for Sussex, top-scored with an unbeaten 126 and shared in a 175-run second-wicket partnership with Ed Joyce (102) as Sussex made 291 for three having won the toss.
That total was always going to prove too much for Unicorns on a dry, slow pitch, especially after the visitors lost openers Michael Thornely and James Ord in the first four overs, and they could only make 147 for nine in reply.
In the day's other match in Group B, Durham avenged last season's semi-final defeat at Taunton with a 14-run win against injury-hit Somerset at Chester-le-Street.
Durham looked to be strolling to victory when, after making 222 for nine batting first, they reduced their opponents to 147 for eight in the 31st over.
But Somerset, runners-up for the last two seasons, battled back through Alex Barrow (72) and George Dockrell (18) and they had got the target down to 18 off eight balls when the former skied a catch on the leg side. In the final over Dockrell was caught at long-off and Somerset were all out for 208.