Ascot Gold Cup winner Colour Vision will put his reputation in the line in the Artemis Goodwood Cup on August 2.
Trained by Mark Johnston until this season, the four-year-old is unbeaten in two races since joining Saeed bin Suroor.
He beat the Mahmood Al Zarooni-trained Opinion Poll last month but will not have to face him this time as the latter has met with a setback.
Instead, his stablemate Lost In The Moment will be his companion.
Godolphin racing manager Simon Crisford said: "We are probably going to run Colour Vision and Lost In The Moment in the Goodwood Cup.
"Opinion Poll had a small setback - a minor bone issue - and is having an mid-season break to hopefully come back for British Champions Day.
"Colour Vision will hopefully defend his Ascot crown but it's obviously going to be a tough race. Better ground than at Ascot should hopefully help him show his turn of foot.
"He's a top-class stayer, and then hopefully there are races at York and Doncaster can come into the equation. He has taken the race well and his work is straightforward.
"Lost In The Moment, we know what he is, a 110 horse, maybe 112 on a good day."
Champion Irish jumps trainer Willie Mullins is to run dual Royal Ascot winner Simenon.
The five-year-old won the Ascot Stakes on the Tuesday of the big meeting and followed up in the Queen Alexandra on the Saturday, ridden on both occasions by Ryan Moore.
Mullins said: "I was looking at a map of Goodwood, and it resembles my gallop at home!
"Maybe it will help give us the eight or 10lb of improvement we need.
"I thought he'd go close in the Supreme at Cheltenham but he came last. I put it down to travelling, and as we have a huge team of horses there, it's hard to mind every horse.
"We changed things for Ascot and I was hoping, not expecting, the first win. The race on the Saturday suited him better and Ryan Moore is very keen to bring the horse over again - that says a lot to me."
John Gosden's Nehaam was just run out of the places at Ascot on Champions Day and was sixth in the Gold Cup, but will have another go at a top prize.
"Nehaam ran well in the Qipco race (in October) and will go to the Goodwood Cup. He's in good form, I'm delighted with him," said Gosden.
Update:
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