Waddock's men visit Minstermen
Wycombe kick-off their 2012/13 League Two campaign with a trip to newly-promoted York on August 18.
Gary Waddock's men, who are seeking an instant return to the third tier following last season's relegation, then host Gillingham three days later before welcoming Bristol Rovers on August 25.
Cheltenham away is on the agenda for Boxing Day, while Exeter are the visitors on New Year's Day
The Chairboys conclude their campaign by hosting Port Vale on April 27.