Walkover for Wawrinka
Third seed Stan Wawrinka moved into the fourth round of the US Open without having to take to the court on Saturday night, while John Isner's defeat left Serena Williams as the only American left in the tournament.
Wawrinka did not have to even hit a ball in anger against Blaz Kavcic, with the Slovenian pulling out of their clash before the start with a foot injury.
Wawrinka will hope it is a good omen because he was also given a walkover in the third round of the Australian Open, which he went on to win.
Isner is no doubt now sick of the sight of Philipp Kohlschreiber after the German 22nd seed knocked the big-serving American out in the third round for the third year in a row to book a shot at Novak Djokovic.
Kohlschreiber's 7-6 (7/4) 4-6 7-6 (7/2) 7-6 (7/4) victory means for the second successive year there are no American men in the fourth round, with only Williams left in the women's tournament.
Tommy Robredo ended the run of 19-year-old Nick Kyrgios with a masterclass of experience versus youth.
Australian Kyrgios is made for a stage like Arthur Ashe under the lights and powered his way into a 5-0 lead.
But Robredo is one of the canniest players around and he worked away at Kyrgios' raw edges to turn the match in his favour and win 3-6 6-3 7-6 (7/4) 6-3.
Robredo beat Roger Federer in the fourth round last year and will attempt to upset another Swiss, third seed Stan Wawrinka, in the last 16 this time.
Fifth seed Milos Raonic ended the run of Victor Estrella Burgos in a tight match that was decided by three tie-breaks.
Estrella Burgos' rise into the top 100 at the age of 34 has been one of the best stories of the season but even his enthusiastic band of fans from the Dominican Republic could not propel him to victory this time.
"For me it was the best week," said Estrella Burgos. "I lost today, but today was my best match. I played at a very good level.
"The three sets were very close. I was serving for the set in the third set. I could not close the set but I'm not too sad."
In the fourth round Raonic will play 10th seed Kei Nishikori, who came into the tournament short on matches because of injury but has been impressive and beat Leonardo Mayer 6-4 6-2 6-3.
Ninth seed Jo-Wilfried Tsonga is through to the fourth round without dropping a set after a 6-4 6-4 6-4 win over Spain's Pablo Carreno Busta.