Wales lock Luke Charteris has been ruled out of Sunday's Six Nations clash with England at Twickenham because of a neck injury.
Edinburgh prop Alasdair Dickinson is out of Scotland clash with France due to a calf injury.
England have made just one change to the team for Sunday's crunch Six Nations clash with Wales at Twickenham.
A Welsh MP has moved to clarify remarks he made on Twitter that questioned Wales skipper Sam Warburton's right to captain his country.
The Celtic League have agreed a deal with Italian rugby chiefs for two of their teams to play in the competition for the next four years.
England locks Joe Launchbury and Courtney Lawes will go into battle on Sunday accompanied by a notable admirer - Wales opponent Alun-Wyn Jones.
Chris Robshaw has demanded England issue a statement of intent against Wales and strike an early World Cup blow.
Andrew Trimble believes Ireland team-mate Iain Henderson has the potential to go far at international level once he bulks out with age.
Jonny May promises to keep Twickenham guessing in Sunday's Six Nations showdown between England and Wales by continuing to operate on instinct.
Ireland have no conflict of interest with Racing Metro over fly-half Johnny Sexton, according to head coach Joe Schmidt.
Sean Lamont is determined to help Scotland end their eight-year wait for a win over France.
Marco Bortolami will lead Italy against Ireland in Dublin on Saturday in the absence of regular captain Sergio Parisse.