Andy Murray has withdrawn from next week's French Open after failing to recover from a back injury picked up at the Rome Masters.
Seventh seed Varvara Lepchenko had to work hard to secure her place in the second round of the Brussels Open on Monday.
Top seed Marion Bartoli was a shock early casualty at the WTA Internationaux de Strasbourg as she was beaten in straight sets by Italy's Camila Giorgi.
Fifth seed Andreas Seppi and former world number one Lleyton Hewitt were big-name first-round casualties at the Open de Nice Cote d'Azur.
Serena Williams clinched her fourth consecutive title in comprehensive fashion as she beat Victoria Azarenka 6-1 6-3 in the final of the Italian Open on Sunday.
Rafa Nadal took just over an hour to send Roger Federer packing and claim the Rome Masters title after winning the 30th ATP Tour clash between the two giants 6-1 6-3.
Rafael Nadal stayed on course for a seventh title in the Italian capital thanks to a stunning semi-final victory against Tomas Berdych.
Andy Murray intends to wait until the middle of the coming week before making a final decision on whether to play in the French Open.
Serena Williams will be gunning for her fourth successive title when she takes on Victoria Azarenka in the final of the Italian Open on Sunday.
Rafael Nadal remained on course for a seventh ATP Rome Masters title after triumphing against compatriot David Ferrer once again, 6-4 4-6 6-2.
Tomas Berdych fought back from 6-2 5-2 down to stun world No 1 Novak Djokovic in the quarter-finals of the Italian Open.
World No 2 Maria Sharapova has blamed "physical problems" after she was forced to pull out of the Rome Open.
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